Is a Prolonged Bleeding Time Associated with an Increased Risk of Hemorrhage after Liver Biopsy?

Kirsten Muri Boberg; Frank Brosstad; Thore Egeland; Tor Egge; Erik Schrumpf

doi:10.1055/s-0037-1614481

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1999; 81(03): 378-381
DOI: 10.1055/s-0037-1614481

Review Article

Schattauer GmbH

Is a Prolonged Bleeding Time Associated with an Increased Risk of Hemorrhage after Liver Biopsy?

Kirsten Muri Boberg

¹From the Medical Department A, Oslo, Norway

,

Frank Brosstad

¹From the Medical Department A, Oslo, Norway

,

Thore Egeland

²Center of Clinical Epidemiology, Oslo, Norway

,

Tor Egge

³Department of Radiology, Rikshospitalet, Oslo, Norway

,

Erik Schrumpf

¹From the Medical Department A, Oslo, Norway

› Author Affiliations

Abstract

Summary

Bleeding time determination is not advised as a general preoperative hemostasis screening test, but it might be useful in some patient groups. Patients referred for liver biopsy frequently have coagulation disturbances and are at risk of hemorrhage. In this prospective study 219 liver biopsies were carried out regardless of a prolonged bleeding time, but with minimum requirements for hemoglobin concentration, platelet count, and tests of the internal and external coagulation pathways. The bleeding time was prolonged in the case of 48 (22%) of the biopsies. Significant bleeding as defined by a hemoglobin decrease of ≥2.0 g/dl occurred in nine patients. Three of these patients were bone marrow transplanted. Patients with a prolonged bleeding time carried a five times higher risk of bleeding (odds ratio = 5.0; confidence interval = 1.1-21.8; p = 0.019). We conclude that the bleeding time may give additional information on the risk of bleeding in some patient groups undergoing liver biopsy.

Full Text

References

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